While present, mutant adrenals are differentiated as evidenced by the presence of enzymes for the final steps in the synthesis of corticosterone, aldosterone, and catecholamines. However, in mutants adrenal cells fail to proliferate postnatally and adrenals atrophy until they have disappeared macroscopically in the adult. ![]() ![]() POMC-null mutant mice are born with adrenal glands that are morphologically indistinguishable from those of their wild-type littermates. To understand the basis for this adrenal defect, we compared the development of adrenal primordia in POMC-null mice and littermate controls. Adult mouse mutants homozygous for an engineered proopiomelanocortin (POMC)-null allele lack macroscopically distinct adrenal glands and circulating adrenal hormones.
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